MENSTRUAL CYCLE AND MENSTRUATION

All living beings great and small have the main function of reproduction including humans.
The menstrual cycle is an integral part of this reproductive function. It is called menses and it is derived from the Latin word meaning monthly.
The main organs involved in this monthly cycle are Hypothalamus and Pituitary and they are located in the brain. The main female sex gland is called the ovary and it is located in the abdomen close to the uterus and the two tubes. The uterus is connected to the outside world by the cervix and the vagina. The chemicals produced by the hypothalamus and pituitary glands are called hormones which in turn act on the ovary which produces its own hormones. They help in the maturation of the egg and preparation of the uterus to receive the egg if fertilised.
If the pregnancy does not occur the prepared lining of the uterus is shed causing bleeding and this is called menstruation.Usually the menstruation starts around the ages of ten to fourteen years, and lasts for forty years in a women's life. The menstrual bleeding lasts three to seven days and blood loss is about 30 - 50 mls. The cycle usually varies between twenty-one to thirty five days.

It is only recently that we have started to understand what triggers the menstrual cycle.
They have found a new chemical called Kisspeptin which is supposed to trigger the hypothalamus to produce a hormone called GnRH.
GIIRH stimulates the pituitary to produces its hormones — follicle stimulating hormone (FSH) and luteinizing hormone (LH). These hormones ultimately cause the egg maturation and ovulation (the release of the mature egg from the ovarian follicle.

Under the influence of FSH, several primordial follicles start maturing but only one becomes the dominant follicle for the cycle.  The growing egg produces oestrogens, The oestrogens produced by the egg stimulate a surge in the production of another hormone LH by the pituitary gland. This surge in LH causes ovulation in the middle of the cycle, about fourteen days after the follicle starts growing.

After the egg is released, the remaining cells of the empty follicle turn into what is called the corpus luteum (Latin for ‘yellow body’) which then produces the second of the female hormones, progesterone, in the second half of the menstrual cycle. In the first two weeks of the menstrual cycle, leading up to ovulation, the oestrogens help the growth of the lining of the womb (the endometrium). In the second two weeks, the progesterone matures or ripens this lining.

            If conception occurs, nutrition and support is provided by this lining for the growing embryo. Progesterone levels remain elevated, ensuring the stability of the womb lining, and enabling the pregnancy to continue. However, if fertilisation does not occur, an abrupt fall in oestrogen and progesterone levels takes place about 10—12 days after ovulation. This drop in hormone levels destabilises the lining of the womb, which is then shed as menstrual flow indicating the end of the ovarian cycle.

Menstruation is a reassuring sign that the ovarian function is normal. A new cycle of egg maturation begins.

At the time of menstruation other specific chemicals called prostaglandins are produced in the endometrium which may be responsible for period cramps, headaches, nausea and dizziness which can accompany a menstrual period.

 

Key points

1.     The ovary, the female sex gland, is the main organ concerned with menstruation, reproduction, production of the female hormones oestrogen and progesterone, and menopause.

2.     The ovary lies dormant from birth to puberty and becomes dormant again at menopause, after four decades of reproductive activity.

3.     It is now being researched what biological catalysts activate, and then end, ovarian activity.

      4.   Oestrogens play the key role in maintaining a woman’s health during the reproductive years.

      5.   There are many issues about menstruation that need to be discussed, such as;

A-Puberty, B-Amenorrhoea,(No Periods), C-Premenstrual tension(PMT),D-Painful Periods,

E-Heavy and Irregular Bleeding, F-Polycystic Ovaries, G-Contraception.

All these problems will be discussed in future posts.

 

 

 

 

REMAINING VULVAL DISORDERS

For the last few posts we have been focusing on various skin and mucous membrane problems that cause vulval pain ,discharge , discomfort and dyspareunia, most of these have already been elaborated on and I will discuss the remaining few today. It is very difficult to discuss all of them as many of them such as psoriasis, tinea, and lichen planus effect almost all parts of the body covered by skin and mucous membrane and they often come under the domain of a dermatologist.
One of the common group of inflammatory conditions of the vulva  are called; 1-Lichen Planus, 2-Lichen Simplex Chronicus, 3- Lichen Sclerosis.

Lichen Planus is an erosive condition of the vulva which can affect both the vagina and the vulva, besides the genital area it can affect the scalp, hair and legs.
It has a reticulated purplish appearance which is very painful and uncomfortable. The diagnosis is confirmed by a biopsy and has a malignant potential, there is no definitive treatment, the patient needs reassurance, local emollients and steroids. Some people have tried testosterones. Recently cyclosporine are being tried.

 The above picture is Lichen Simplex Chronicus.

This also causes itching and leads to chronic rubbing and scratching , this usually affects the labia Majora, Labia Minora, and Labia Crural Folds. The vagina is not involved, this can result from chronic infection , anxiety conditions such as Psoriasis, Eczema. The skin becomes thick and leathery as you can see in the above picture and brownish. So the treatment is again reassurance, tranquillisers, antihistamines, anti pruritic agents and corticosteroids. The cause of chronic anxiety or infection causing the itch also needs to be treated.

Lichen Sclerosis is a chronic inflammatory disorder of the skin affecting both genital and extra genital skin such as the armpit, neck and shoulder and sub memory fold below the breast.
It can occur at any age including children, usually if it occurs in young girls it goes away as they mature. Most often it occurs in post menopausal women. Again like other vulval skin problems it causes itching and pain. The skin gets thickened and causes adhesions. The local tissues are destroyed. We are not sure what causes this, but like Lichen Planus it is thought to be auto immune.
Autoimmunity is a process in which the body fails to recognize itself and therefore attacks its own cell and tissues.
The treatment consists of avoiding commercial body washes and antiseptic solutions. Washing with a freshly made saline solution of two teaspoons full of salt with one litre of water is very soothing.
You need to do this twice daily for several weeks, then repeat the wash as required.
Daily strong tropical steroids are required on your doctors advice.

Lichen Planus and Lichen Sclerosis both have a five percent cancer potential , therefore it is very important to have six monthly regular appointments with your gynaecologist.



The vulval conditions described above need patient education, psychological  counselling, avoidance of commercial gimmicks, symptomatic treatment, saline washes, emollient's, corticosteroids, treatment for any inter current infections, ie: Thrush, (Candiasis) and above all regular check ups, and never treat yourself without correct diagnosis by a professional.

Bartholin's Cyst and Abscess

Bartholin gland is a small gland that lies in the entrance to the vagina and basically a small amount of fluid keeps the vagina moist which is useful during sexual intercourse. It has a small gland which carries the fluid to the vagina. If there is any infection the area, this little duct gets blocked and can cause a Bartolin's Cyst or Abcess. The important thing to know is that if it keeps happening it needs attention to exclude STI and often it requires drainage.

The above picture show the location of a swollen Bartholin Cyst and it's drainage.

Genital Herpes

Genital Herpes is caused by type one and type two herpes virus, initially not much attention was paid to this, but nowadays it is the most commonly transmitted disease. To prevent from yourself from getting herpes is to always use condoms, use suppressive viral therapy to protect your partner and avoid skin trauma by using silicone based lubricants.
The diagnosis is made by a swab test from the lesion, the blood tests are not so accurate. The initial attack of herpes is very painful. The treatment is anti viral drugs called Valtrex, Famvir and Zovirax.
The frequent occurrence can be treated by taking one tablet daily, this also protects transmission to the partner. It is very important to avoid herpes in the last few months of pregnancy as it can be dangerous to the newborn baby, and if the mother has an active rash on the vulva, the baby should be delivered by caesarean section.


Human Papilloma Virus is another virus which affects the female genital organs, particularly the cervix and the vagina and the vulva. The visible disease that is causes is the warts, otherwise it causes changes in the cervix which in the long term can lead to cervical cancer. To avoid cervical cancer that the smear test is implemented around the western world.
Please ensure that you have regular smear tests.

Another cause of vaginal discharge in post menopausal women is due to lack of oestrogens and it can be easily relieved by local oestrogen. However any women who suffers from irregular bleeding in the older age group must be investigated to exclude malignancy.

Often the vaginal discharge is due a foreign body and often this is a forgotten tampon.
The four tests which are useful for all these diagnoses  is a cervical smear, swabs, biopsy and ultrasound.

You may have to read or research more to increase your knowledge on vulval vaginal infections.
And this is all from me on this topic.

In future posts we will continue our journey on Womens Health problems.